Sperm DNA Fragmentation Comet Test - Exact®

Beyond the Count:

Discover the Genetic Health of Your Sperm

A standard semen analysis might show "normal" results, yet many couples still face unexplained infertility or recurrent miscarriages. While standard tests look at the "packaging" of the sperm, the Comet Test looks at the "cargo"—the DNA itself.

Why Choose the Comet Test?

The Exact® test directly measures total sperm DNA Fragmentation, including both single and double strand DNA breaks, with exceptional accuracy. Even when semen analysis is normal, high levels of this type of DNA damage can reduce the chances of conception. Knowing your total SDF damage score helps to identify whether targeted changes can be made to try and improve your sperm health, and helps your clinician to look for and address any reversible risk factors.

High levels of DNA fragmentation can:

Reduce the chances of natural conception.
Lead to failed IVF or IUI cycles.
Increase the risk of early pregnancy loss.

Unlike standard in-clinic tests that offer a 24-hour turnaround, the Comet Exact® Test involves advanced molecular analysis.

Process: We use a precise "electrophoresis" process where DNA is pulled through a gel to reveal the "tail" of the comet, measuring the exact extent of fragmentation.
Turnaround Time: Results are typically ready within 2–3 weeks from the date the sample is received at our partner laboratory, Examen.
Actionable Results: You will receive a "Comet Score". If the score is high, we provide actionable lifestyle advice and clinical recommendations to improve your fertility potential.

We specifically recommend the Comet Test for:

Unexplained Infertility: Couples with normal semen analysis but no pregnancy.
Recurrent Miscarriage: Men in couples who have experienced multiple pregnancy losses.
Failed Assisted Conception: Patients who have had unsuccessful IVF or ICSI cycles.
Specific Risk Factors: Men over age 40 or those with lifestyle risks like smoking, high BMI, or a varicocele.

Patient FAQ

Can high DNA fragmentation be treated?

Absolutely. It is often caused by oxidative stress, which can be improved through lifestyle changes, antioxidant supplements, or treating underlying issues like a varicocele.

When should I re-test?

Most men see significant improvement after 90 days of targeted health changes; therefore, re-testing after 3 months is usually recommended.

Why is this test priced higher?

The fee covers a specialized collection kit, secure clinical shipping to our reference lab, and advanced molecular analysis. It is an investment in "answers" to help avoid the emotional and financial cost of failed IVF cycles.